the closest thing i’ve heard of (and granted this isn’t going to very close) is a post titled “Multiple Scanners” where stoops (who was never heard from again after this post) said he could get multiple devices of the same type plugged in at the same time and was manipulating the registry to get it done. If there is a solution to what you’re trying to do, I think it is in that direction – otherwise I would say, no you need to have your driver under %windir%twain_32 like everybody else.
why would want to do this? (just curious)