Not talking from experience, but I’ve been thinking about this for a while. The closest I have come to problem are these two articles:
http://msdn.microsoft.com/sv-se/magazine/cc301832(en-us).aspx
http://forums.asp.net/p/1226851/2204437.aspx
My (rather limited) understanding of asp.net in relation to getting it to play nice with twain is that you’re going to have trouble depending on your zone’s security, largely because to play with twain you need to play with window messages, messageloops and possibly override wndproc depending on your programming language. Most of those require in .net a level of security you don’t typically have by default in any of the restricted zones.
If you were trying to get some asp.net code to run within your company’s network|domain I believe those articles will go a long way toward getting you started. From there you would just need a .net dll in the gac to talk to twain and I don’t think that would be too hard to find..
But if you were trying to get some asp.net code to run outside of your company|domain I think you will have more trouble especially if you start to think about the problems with browsers other than ie.
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